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549 results

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Page 1
Did you mean pet and bone (9,955 results)?
Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis.
Suh J, Kim NK, Shim W, Lee SH, Kim HJ, Moon E, Sesaki H, Jang JH, Kim JE, Lee YS. Suh J, et al. Cell Metab. 2023 Feb 7;35(2):345-360.e7. doi: 10.1016/j.cmet.2023.01.003. Cell Metab. 2023. PMID: 36754021 Free article.
Mitochondrial components have been abundantly detected in bone matrix, implying that they are somehow transported extracellularly to regulate osteogenesis. ...We also show that mitochondrial fusion promoter M1, which induces Opa1 expression, impedes osteogenesis, whereas o …
Mitochondrial components have been abundantly detected in bone matrix, implying that they are somehow transported extracellularly to …
STING suppresses bone cancer pain via immune and neuronal modulation.
Wang K, Donnelly CR, Jiang C, Liao Y, Luo X, Tao X, Bang S, McGinnis A, Lee M, Hilton MJ, Ji RR. Wang K, et al. Nat Commun. 2021 Jul 27;12(1):4558. doi: 10.1038/s41467-021-24867-2. Nat Commun. 2021. PMID: 34315904 Free PMC article.
Patients with advanced stage cancers frequently suffer from severe pain as a result of bone metastasis and bone destruction, for which there is no efficacious treatment. Here, using multiple mouse models of bone cancer, we report that agonists of the immune r …
Patients with advanced stage cancers frequently suffer from severe pain as a result of bone metastasis and bone destruction, f …
Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses.
Duan M, Nguyen DC, Joyner CJ, Saney CL, Tipton CM, Andrews J, Lonial S, Kim C, Hentenaar I, Kosters A, Ghosn E, Jackson A, Knechtle S, Maruthamuthu S, Chandran S, Martin T, Rajalingam R, Vincenti F, Breeden C, Sanz I, Gibson G, Lee FE. Duan M, et al. Cell Rep. 2023 Jul 25;42(7):112682. doi: 10.1016/j.celrep.2023.112682. Epub 2023 Jun 24. Cell Rep. 2023. PMID: 37355988 Free PMC article.
Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). ...
Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasm …
Stereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine: Phase 3 Results of NRG Oncology/RTOG 0631 Randomized Clinical Trial.
Ryu S, Deshmukh S, Timmerman RD, Movsas B, Gerszten P, Yin FF, Dicker A, Abraham CD, Zhong J, Shiao SL, Tuli R, Desai A, Mell LK, Iyengar P, Hitchcock YJ, Allen AM, Burton S, Brown D, Sharp HJ, Dunlap NE, Siddiqui MS, Chen TH, Pugh SL, Kachnic LA. Ryu S, et al. JAMA Oncol. 2023 Jun 1;9(6):800-807. doi: 10.1001/jamaoncol.2023.0356. JAMA Oncol. 2023. PMID: 37079324 Free PMC article. Clinical Trial.
Secondary end points included treatment-related toxic effects, quality of life, and long-term effects on vertebral bone and spinal cord. RESULTS: A total of 339 patients (mean [SD] age of SRS group vs cEBRT group, respectively, 61.9 [13.1] years vs 63.7 [11.9] years; 114 [ …
Secondary end points included treatment-related toxic effects, quality of life, and long-term effects on vertebral bone and spinal co …
Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development.
Tani S, Okada H, Onodera S, Chijimatsu R, Seki M, Suzuki Y, Xin X, Rowe DW, Saito T, Tanaka S, Chung UI, Ohba S, Hojo H. Tani S, et al. Cell Rep. 2023 Apr 25;42(4):112276. doi: 10.1016/j.celrep.2023.112276. Epub 2023 Mar 24. Cell Rep. 2023. PMID: 36965484 Free article.
Here, we introduce an integrative method to model human skeletal development by combining in vitro sclerotome induction from human pluripotent stem cells and in vivo endochondral bone formation by implanting the sclerotome beneath the renal capsules of immunodeficient mice …
Here, we introduce an integrative method to model human skeletal development by combining in vitro sclerotome induction from human pluripote …
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Farr JN, et al. J Clin Invest. 2023 Apr 17;133(8):e162519. doi: 10.1172/JCI162519. J Clin Invest. 2023. PMID: 36809340 Free PMC article.
Thus, we developed a mouse model (p16-LOX-ATTAC) that allowed for inducible SnC elimination (senolysis) in a cell-specific manner and compared the effects of local versus systemic senolysis during aging using bone as a prototype tissue. Specific removal of Sn osteocytes pr …
Thus, we developed a mouse model (p16-LOX-ATTAC) that allowed for inducible SnC elimination (senolysis) in a cell-specific manner and compar …
The diagnostic value of metagenomic next⁃generation sequencing in infectious diseases.
Duan H, Li X, Mei A, Li P, Liu Y, Li X, Li W, Wang C, Xie S. Duan H, et al. BMC Infect Dis. 2021 Jan 13;21(1):62. doi: 10.1186/s12879-020-05746-5. BMC Infect Dis. 2021. PMID: 33435894 Free PMC article.
Peripheral blood leukocytes, C-reactive protein (CRP), procalcitonin (PCT) and neutrophil counts were measured, and the concentrations of IL-2, IL-4, IL-6, TNF-alpha, IL-17A, IL-10 and INF-gamma in the serum were determined by ELISA. ...Blood was the most abundant type of …
Peripheral blood leukocytes, C-reactive protein (CRP), procalcitonin (PCT) and neutrophil counts were measured, and the concentration …
Dynamics of bone tissue formation in tooth extraction sites. An experimental study in dogs.
Cardaropoli G, Araújo M, Lindhe J. Cardaropoli G, et al. J Clin Periodontol. 2003 Sep;30(9):809-18. doi: 10.1034/j.1600-051x.2003.00366.x. J Clin Periodontol. 2003. PMID: 12956657
After seven days this clot was in part replaced with a provisional matrix (PCT). On day 14, the tissue of the socket was comprised of PM and woven bone. ...CONCLUSION: The healing of an extraction socket involved a series of events including the formation of a coagu …
After seven days this clot was in part replaced with a provisional matrix (PCT). On day 14, the tissue of the socket was comprised of …
Clinical and molecular characteristics of methicillin-resistant Staphylococcus aureus in bone and joint infection among children.
Fu P, Nijiati Y, Li T, Wu X, Wang Z, Zhou J, Wang C, Ning B. Fu P, et al. Ann Clin Microbiol Antimicrob. 2023 Nov 22;22(1):104. doi: 10.1186/s12941-023-00654-3. Ann Clin Microbiol Antimicrob. 2023. PMID: 37993871 Free PMC article.
OBJECTIVE: To investigate the characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) in bone and joint infection (BJI) among children. METHODS: A total of 338 patients diagnosed with BJI from 2013 to 2022 in Children's Hospital of Fudan University were enrol …
OBJECTIVE: To investigate the characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) in bone and joint infection (BJI) …
549 results